Professor Remus John Lupin (10 March, 1960- 2 May, 1998) also known as Moony, was a half-blood wizard and the only son of Lyall and Hope Lupin. He was afflicted with lycanthropy (being a werewolf) during his childhood, as Fenrir Greyback's revenge against Lyall Lupin. He attended Hogwarts School of Witchcraft and Wizardry; he became best friends with Sirius Black (Padfoot), James Potter (Prongs) and Peter Pettigrew (Wormtail). Together they created the Maurauder's Map. After Hogwarts, Remus and his friends joined the Order of the Phoenix and fought in the First Wizarding War. However, Pettigrew betrayed James and Lily Potter to Tom Marvolo Riddle (Lord Voldemort) and Remus lost all of his closest friends in various ways by the end of the War, though he and Sirius Black later reclaimed their friendship.

Remus taught at Hogwarts as Professor of Defense Against the Dark Arts during the 1993-1994 school year. He was also a teacher of Harry Potter, whom he taught how to conjure a Patronus, but resigned after Severus Snape revealed to the public that Remus was a werewolf. He fought against the Death Eaters once more in the Second Wizarding War, during which he lost his friend Sirius Black. In 1997, Remus married fellow Order member Nymphadora Tonks and had a son, Edward Remus "Teddy" Lupin. Remus fought at the Battle of Hogwarts, during which Remus was killed by the Death Eater, Antonin Dolohov, during the same battle in 1998. 

Nymphadora Lupin (Who preferred to be known as Tonks) (1973 – 2 May, 1998), more commonly known as Tonks, was a half blood, and the only child of Ted and Andromeda Tonks (Black), and a Metamorphmagus. She attended Hogwarts School of Witchcraft and Wizardry from 1984 to 1991 and was sorted into Hufflepuff House.  After leaving Hogwarts, Tonks joined the Ministry of Magic and trained to become an Auror under the watchful eye of Alastor "Mad Eye" Moody, qualifying in 1994. In 1995, she joined the Second Order of the Phoenix, working undercover in the Ministry and helping to guard the Department of Mysteries. In June of 1996, she fought in the Battle of the Department of Mysteries and at some point fell in love with Remus Lupin.

Remus, a werewolf, felt he was too poor, old, and dangerous for her and thus rejected her feelings, although he felt the same way. In the wake of the (announced) return of Voldemort, Tonks was assigned to Hogsmeade as part of the Auror task force sent to guard Hogwarts. Tonks later fought in the Battle of the Astronomy Tower and, after seeing the love Fleur Delacour held for Fleur Delacour despite his injuries, publicly declared her love for Remus. The two were married in the summer of 1997. Tonks became pregnant shortly after, and Remus began to worry that he had passed on his werewolf condition to his son, and though this proved not to be the case, Teddy nevertheless did inherit his mother's metamorphic abilities. Tonks gave birth to a son, Teddy (named after her late father, Ted Tonks), shortly after Easter in 1998. In May of that same year, Tonks fought in the Battle of Hogwarts, and was killed by her aunt, Bellatrix Lestrange.